Methyl 5-bromovalerate → Methyl 5-methoxypentanoate

HRID 396696

반응식

HRID 396696 반응식
Br[CH2:2][CH2:3][CH2:4][CH2:5][C:6]([O:8][CH3:9])=[O:7].[CH3:10][O-:11].[Na+]>CO>[CH3:10][O:11][CH2:2][CH2:3][CH2:4][CH2:5][C:6]([O:8][CH3:9])=[O:7]

참가 물질

4

반응물 2

HCID 79557Methyl 5-bromovalerateHCID 10942334Sodium Methoxide

생성물 1

HCID 542362Methyl 5-methoxypentanoate수율 97.8%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of methyl 5-bromovalerate (10.0 g, 51.3 mmol), NaOMe (12.3 ml of 25% solution, 53.8 mmol) in 100 ml of MeOH was refluxed for 5 hrs. The MeOH was removed in vacuo and residue was partitioned between CHCl3 (200 ml) and water (50 ml). The organic layer was separated and washed with water (100 ml). After drying (Na2SO4) and evaporation of solvent, methyl 5-methoxyvalerate (7.33 g, 97.8%) was obtained as a colorless oil.

후처리

  1. customThe MeOH was removed in vacuo and residue
  2. customwas partitioned between CHCl3 (200 ml) and water (50 ml)
  3. customThe organic layer was separated
  4. washwashed with water (100 ml)
  5. customAfter drying
  6. custom(Na2SO4) and evaporation of solvent

출처 및 근거

ORD 기록
ord-8e84b30941c74fc3ace4e024b18dadc9
출처 데이터셋
uspto-grants-2003_08
특허 번호
US06608086B2

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