참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | Methyl 5-methoxypentanoate | HCID 542362 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 5-methoxypentanoic Acid | HCID 285825 | 79.6% |
반응 단계
Methyl 5-methoxyvalerate (7.33 g, 50.2 mmol) and KOH (14.4 g, 0.256 mol) were dissolved into a mixture of 50 ml of water and 150 ml of MeOH. The solution was stirred at 0° C. for 2 hrs then MeOH was removed in vacuo. After washed by CHCl3 (50 ml), the aqueous layer was acidified to pH=1 by 2N HCl and extracted by Et2O (2×100 ml). Organic layers were combined, washed with water (100 ml) and dried over Na2SO4. After filtration and evaporation of solvent, 5-methoxyvaleric acid (5.27 g, 79.6%) was obtained as a colorless oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US06608086B2 |
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| 출처 데이터셋 | uspto-grants-2003_08 |
|---|
| ORD ID | ord-1783a2a167f14a37867df94f8e64fcfc |
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| 출처 메모 | uspto-grants-2003_08 |
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