Water → 4-(2-Furyl)Aniline Hydrochloride

HRID 396753노트

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HRID 396753 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[O:11][CH:12]=[CH:13][CH:14]=2)=[CH:6][CH:5]=1)([O-])=O.O>C(O)C>[O:11]1[CH:12]=[CH:13][CH:14]=[C:10]1[C:7]1[CH:8]=[CH:9][C:4]([NH2:1])=[CH:5][CH:6]=1

참가 물질

4

반응물 2

HCID 962WaterHCID 6049692-(4-Nitrophenyl)furan

생성물 1

HCID 41911054-(2-Furyl)Aniline Hydrochloride

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
70 °C

실험 절차

To a suspension of 2-(4-nitrophenyl)furan (0.378 g, 2 mmol, prepared according to the method of Heterocycles, 1990, 31, 1951) in ethanol (20 mL) was heated to 70° C. and added stannous chloride dihydrate (2.26 g, 10 mmol) and the mixture was stirred for 2 hours. The reaction mixture was cooled to room temperature and poured into water (50 mL), the whole was extracted with ethyl acetate (30 mL×2). The organic layer was dried over Na2SO4, filtered through celite and concentrated to give the crude subtitle compound (0.35 g).

후처리

  1. customprepared
  2. temperatureThe reaction mixture was cooled to room temperature
  3. extractionthe whole was extracted with ethyl acetate (30 mL×2)
  4. dry with materialThe organic layer was dried over Na2SO4
  5. filtrationfiltered through celite and
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-647ab23400524ea8824f626b1ac31a5a
출처 데이터셋
uspto-grants-2003_08
특허 번호
US06608095B2

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