Ammonium Hydroxide → 3-Chloro-4-fluorobenzenesulfonamide

HRID 396805노트

반응식

HRID 396805 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([S:9](Cl)(=[O:11])=[O:10])[CH:5]=[CH:6][C:7]=1[F:8].[OH-].[NH4+:14]>C(Cl)Cl>[Cl:1][C:2]1[CH:3]=[C:4]([S:9]([NH2:14])(=[O:11])=[O:10])[CH:5]=[CH:6][C:7]=1[F:8]

참가 물질

4

반응물 2

HCID 14923Ammonium HydroxideHCID 1452223-Chloro-4-fluorobenzenesulphonyl chloride

생성물 1

HCID 75098833-Chloro-4-fluorobenzenesulfonamide수율 68.2%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 3-chloro-4-fluorobenzenesulfonyl chloride (2.29 g, 10 mmol) in methylene chloride (30 mL) was added 25% ammonium hydroxide (10 mL) at room temperature and the mixture was stirred for 1 hour. The solvent was removed in vacuo. The residue was redissolved in ethyl acetate (50 mL) and the whole washed with water and brine. After dried over MgSO4 and concentration in vacuo. The resulting solid was recrystallized from ether-hexane to give the title compound (1.429 g, 68.2% yield).

후처리

  1. customThe solvent was removed in vacuo
  2. dissolutionThe residue was redissolved in ethyl acetate (50 mL)
  3. washthe whole washed with water and brine
  4. dry with materialAfter dried over MgSO4 and concentration in vacuo
  5. customThe resulting solid was recrystallized from ether-hexane

출처 및 근거

ORD 기록
ord-35ed3c7eae97476587ee23a525a81a07
출처 데이터셋
uspto-grants-2003_08
특허 번호
US06608095B2

반응 노트

불러오는 중…