Ethyl trifluoroacetate → HCID 22316660, 화합물

HRID 396860노트

반응식

HRID 396860 반응식
[F:1][C:2]1[CH:7]=[C:6]([C:8]2[N:9]=[CH:10][S:11][CH:12]=2)[CH:5]=[CH:4][C:3]=1[C:13](=[O:15])[CH3:14].[F:16][C:17]([F:24])([F:23])[C:18](OCC)=[O:19].C[O-].[Na+]>C(OC)(C)(C)C>[F:16][C:17]([F:24])([F:23])[C:18](=[O:19])[CH2:14][C:13]([C:3]1[CH:4]=[CH:5][C:6]([C:8]2[N:9]=[CH:10][S:11][CH:12]=2)=[CH:7][C:2]=1[F:1])=[O:15]

참가 물질

5

반응물 3

HCID 9794Ethyl trifluoroacetateHCID 10942334Sodium MethoxideHCID 223166161-[2-Fluoro-4-(4-thiazolyl)phenyl]ethanone

생성물 1

HCID 22316660HCID 22316660, 화합물수율 100.3%

시약·촉매·용매 1

HCID 15413tert-Butyl methyl ether용매

실험 절차

To a stirred solution of 1-[2-fluoro-4-(1,3-thiazol-4-yl)phenyl]-1-ethanone (2.03 g, 9.18 mmol) in t-butylmethylether (60 ml) was added ethyl trifluoroacetate (1.56 g, 11.01 mmol), sodium methoxide (28 wt. % solution in methanol; 2.49 ml, 11.01 mmol) at 0° C., and the mixture was stirred for 3 hours. The mixture was extracted with ethyl acetate. The organic layer was washed with brine, dried over MgSO4, and concentrated in vacuo to give title compound (2.92 g, 99% yield). The compound was used for next reaction without purification.

후처리

  1. extractionThe mixture was extracted with ethyl acetate
  2. washThe organic layer was washed with brine
  3. dry with materialdried over MgSO4
  4. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-320f7f37e27f4eb8a551100ecf686c1c
출처 데이터셋
uspto-grants-2003_08
특허 번호
US06608095B2

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