Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
O-benzyl-N-((tert-butoxy)carbonyl)-L-tyrosine → (2S)-6-[[(2S)-3-(4-benzyloxyphenyl)-2-(tert-butoxycarbonylamino)propanoyl]amino]-2-[isobutyl(p-tolylsulfonyl)amino]hexanoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | O-benzyl-N-((tert-butoxy)carbonyl)-L-tyrosine | HCID 98763 | — |
| 반응물 | Nalpha-isobutyl-Nalpha-(4-methylbenzenesulfonyl)-L-lysine | HCID 23552860 | — |
| 생성물 | (2S)-6-[[(2S)-3-(4-benzyloxyphenyl)-2-(tert-butoxycarbonylamino)propanoyl]amino]-2-[isobutyl(p-tolylsulfonyl)amino]hexanoic acid | HCID 508608 | — |
반응 단계
The title compound was prepared from Nα-isobutyl-Nα-(4-methylbenzenesulfonyl)-L-lysine (100 mg, 0.29 mmol, example 1, step E) as described in general procedure Bc using commercially available Nα-tert-butoxycarbonyl-O-benzyl-L-tyrosine (111 mg, 0.3 mmol). The final product was triturated with ether to yield 145 mg (68%) of the desired material.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06608100B1 |
| 출처 데이터셋 | uspto-grants-2003_08 |
| ORD ID | ord-f2ae4d321a844118a385077e3f89bc36 |
| 출처 메모 | uspto-grants-2003_08 |