3-Methoxypropanoyl chloride → N-[2-Chloro-4-(2-hydroxy-2-methylpropyl)amino-3-quinolinyl]-3-methoxypropanamide

HRID 396990노트

반응식

HRID 396990 반응식
[CH3:1][O:2][CH2:3][CH2:4][C:5](Cl)=[O:6].[NH2:8][C:9]1[C:10]([Cl:25])=[N:11][C:12]2[C:17]([C:18]=1[NH:19][CH2:20][C:21]([CH3:24])([OH:23])[CH3:22])=[CH:16][CH:15]=[CH:14][CH:13]=2>C(#N)C>[Cl:25][C:10]1[C:9]([NH:8][C:5](=[O:6])[CH2:4][CH2:3][O:2][CH3:1])=[C:18]([NH:19][CH2:20][C:21]([OH:23])([CH3:22])[CH3:24])[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[N:11]=1

참가 물질

4

반응물 2

HCID 27597283-Methoxypropanoyl chlorideHCID 226726541-((3-Amino-2-chloroquinolin-4-yl)amino)-2-methylpropan-2-ol

생성물 1

HCID 22672655N-[2-Chloro-4-(2-hydroxy-2-methylpropyl)amino-3-quinolinyl]-3-methoxypropanamide수율 92.7%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

3-Methoxypropionyl chloride (5.5 g, 0.045 mole) was slowly added with stirring to a solution of 1[(3-amino-2-chloro-4-quinolinyl)amino]-2-methyl-2-propanol (10 g, 0.038 mole) in acetonitrile (140 mL). After the addition was completed, the reaction mixture was heated at reflux for 30 minutes then allowed to stir at room temperature overnight. The reaction mixture was filtered to provide 12.4 g of the desired product as a solid.

후처리

  1. additionAfter the addition
  2. temperaturethe reaction mixture was heated
  3. temperatureat reflux for 30 minutes
  4. filtrationThe reaction mixture was filtered

출처 및 근거

ORD 기록
ord-4733427d20854cc09c18499234b72b25
출처 데이터셋
uspto-grants-2003_08
특허 번호
US06608201B2

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