Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Cortisol → Hydrocortisone 4-bromobutanoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Cortisol | HCID 5754 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 4-Bromobutyryl chloride | HCID 70225 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 생성물 | Hydrocortisone 4-bromobutanoate | HCID 86606384 | — |
반응 단계
Five portions of 4-bromobutanoylchloride (0.35 ml×5) and potassium carbonate (0.4 g×5) were added in 24 hours to a solution of hydrocortisone (1 g) in CHCl3 dried over P2O5 and stirred for 5 days. The solution was treated with water, the organic phase was separated, dried (Na2SO4) and deprived of the solvent at reduced pressure.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06610676B1 |
| 출처 데이터셋 | uspto-grants-2003_08 |
| ORD ID | ord-df776e41bca7483791702b15ebb337ba |
| 출처 메모 | uspto-grants-2003_08 |