Morpholine → 5-(4-Morpholin-4-yl-6-oxo-6,7-dihydro-pyrrolo[2,3-D]pyrimidin-5-ylidenemethyl)-1H-pyrrole-2-carboxylic Acid (2-Morpholin-4-yl-ethyl)-amide

HRID 397391노트

반응식

HRID 397391 반응식
[N:1]1([CH2:7][CH2:8][NH:9][C:10]([C:12]2[NH:13][C:14]([CH:17]=[C:18]3[C:26]4[C:25](Cl)=[N:24][CH:23]=[N:22][C:21]=4[NH:20][C:19]3=[O:28])=[CH:15][CH:16]=2)=[O:11])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[NH:29]1[CH2:34][CH2:33][O:32][CH2:31][CH2:30]1>>[N:1]1([CH2:7][CH2:8][NH:9][C:10]([C:12]2[NH:13][C:14]([CH:17]=[C:18]3[C:26]4[C:25]([N:29]5[CH2:34][CH2:33][O:32][CH2:31][CH2:30]5)=[N:24][CH:23]=[N:22][C:21]=4[NH:20][C:19]3=[O:28])=[CH:15][CH:16]=2)=[O:11])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

참가 물질

3

반응물 2

HCID 8083MorpholineHCID 865865025-(4-chloro-6-oxo-6,7-dihydro-pyrrolo[2,3-d]pyrimidin-5-ylidenemethyl)-1H-pyrrole-2-carboxylic acid (2-morpholin4-yl-ethyl)-amide

생성물 1

HCID 853317715-(4-Morpholin-4-yl-6-oxo-6,7-dihydro-pyrrolo[2,3-D]pyrimidin-5-ylidenemethyl)-1H-pyrrole-2-carboxylic Acid (2-Morpholin-4-yl-ethyl)-amide수율 35%

실험 절차

The title compound (35% yield) was prepared from 5-(4-chloro-6-oxo-6,7-dihydro-pyrrolo[2,3-d]pyrimidin-5-ylidenemethyl)-1H-pyrrole-2-carboxylic acid (2-morpholin-4-yl-ethyl)-amide and morpholine according to the procedure described for Example 14. MS-EI 453 [MZ+].

출처 및 근거

ORD 기록
ord-c3c6f5efee68411887bbdf372e4b197b
출처 데이터셋
uspto-grants-2003_08
특허 번호
US06610688B2

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