Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → Methyl 2-(methylamino)-2-phenylacetate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Methanamine, hydrochloride (1:1) | HCID 11637 | — |
| 반응물 | Benzeneacetic acid, alpha-bromo-, methyl ester | HCID 137806 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 촉매 | Benzyl triethylammonium chloride | HCID 66133 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | Methyl 2-(methylamino)-2-phenylacetate | HCID 13852358 | 71.2% |
반응 단계
In this example a mixture containing 30.7 g of methyl bromo-phenylacetate, 36.2 g of methyl ammonium chloride (i.e. CH3NH3Cl); 3.0 g of benzyltriethylammonium chloride and 67.5 g of sodium bicarbonate in about 300 ml of methylene chloride (and about 25 ml of water) was warmed to refluxed and refluxed for about 18 hours. The mixture was then cooled and washed three times with water, dried over magnesium sulfate and concentrated by vacuum evaporation affording 17.1 g of the title compound as an oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04723031 |
| 출처 데이터셋 | uspto-grants-1988_02 |
| ORD ID | ord-c156814239954cc794d18661347d1e7d |
| 출처 메모 | uspto-grants-1988_02 |