Water → 2-(1H-Tetrazol-1-YL)benzonitrile

HRID 397514노트

반응식

HRID 397514 반응식
[N:1]1([C:6]2[CH:14]=[CH:13][CH:12]=[CH:11][C:7]=2[C:8]([NH2:10])=O)[CH:5]=[N:4][N:3]=[N:2]1.[OH-].COC(NS([NH3+])(=O)=O)=O.O>O1CCCC1>[N:1]1([C:6]2[CH:14]=[CH:13][CH:12]=[CH:11][C:7]=2[C:8]#[N:10])[CH:5]=[N:4][N:3]=[N:2]1

참가 물질

5

반응물 3

HCID 962WaterHCID 8559562-(1H-Tetrazol-1-YL)benzamideHCID 21866229(Methoxycarbonylsulfamoyl)ammonium hydroxide

생성물 1

HCID 218662732-(1H-Tetrazol-1-YL)benzonitrile

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 2-Tetrazol-1-yl-benzamide (1.5 g, 7.9 mmol) in tetrahydrofuran (50 ml) was added (methoxycarbonylsulfamoyl)ammonium hydroxide, inner salt (2.8 g, 11.8 mmol) in three portions over 1.5 h. Water was added and the reaction mixture was extracted with ethyl acetate. The combined organic layers were washed with brine. Drying and solvent evaporation gave 2-Tetrazol-1-yl-benzonitrile; 1H NMR (CDCl3, 400 MHz) δ9.27 (s, 1H), 7.90 (m, 3H), 7.72 (m, 1H).

후처리

  1. extractionthe reaction mixture was extracted with ethyl acetate
  2. washThe combined organic layers were washed with brine
  3. customDrying
  4. customsolvent evaporation

출처 및 근거

ORD 기록
ord-aeb154c3c6f647eb8daeba1f1110446d
출처 데이터셋
uspto-grants-2003_08
특허 번호
US06610701B2

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