Potassium Hydroxide → 6-fluoro-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole

HRID 397616노트

반응식

HRID 397616 반응식
[F:1][C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[CH:7][NH:8]2)=[CH:4][CH:3]=1.[NH:11]1[CH2:16][CH2:15][C:14](=O)[CH2:13][CH2:12]1.[OH-].[K+]>CO>[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([C:14]3[CH2:15][CH2:16][NH:11][CH2:12][CH:13]=3)=[CH:7][NH:8]2)=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 14797Potassium HydroxideHCID 337214-PiperidoneHCID 3512786-Fluoroindole

생성물 1

HCID 110530726-fluoro-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of 6-fluoroindole (2 g, 15 mmol) and 4-piperidone (3 g, 19.6 mmol) in 2 N solution of KOH in MeOH (60 mL) was stirred at reflux for 72 h. The mixture was concentrated to ¼ volume, diluted with H20 and filtered affording 2.5 g (77%) as a pale yellow solid: mp 202-204° C.; MS (APCI) m/z 217 [M+H]+.

후처리

  1. temperatureat reflux for 72 h
  2. concentrationThe mixture was concentrated
  3. additiondiluted with H20
  4. filtrationfiltered
  5. customaffording 2.5 g (77%) as a pale yellow solid

출처 및 근거

ORD 기록
ord-220836493af94b11ad7e9d570f8a52ea
출처 데이터셋
uspto-grants-2003_08
특허 번호
US06610712B2

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