Thionyl Chloride → methyl (2S)-piperidine-2-carboxylate hydrochloride

HRID 397657

반응식

HRID 397657 반응식
S(Cl)([Cl:3])=O.[C:5]([C@@H]([C@H](C(O)=O)O)O)(O)=O.[NH:15]1[CH2:20][CH2:19][CH2:18][CH2:17][C@H:16]1[C:21]([OH:23])=[O:22]>CO>[ClH:3].[CH3:5][O:22][C:21]([C@@H:16]1[CH2:17][CH2:18][CH2:19][CH2:20][NH:15]1)=[O:23]

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 69946027(2S)-2-Piperidinecarboxylic acid L-tartrate

생성물 1

HCID 13246232methyl (2S)-piperidine-2-carboxylate hydrochloride

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Thionyl chloride (161 ml) was added dropwise to a suspension of (2S)-2-piperidinecarboxylic acid L-tartrate (60 g) [see Preparation 1] in methanol (800 ml) at 0° C. The reaction mixture was stirred for 18 hours at room temperature after which time the solvent was removed under reduced pressure and the product azeotroped with toluene, precipitated out using methanol and filtered to afford (2S)-2-(methoxycarbonyl)piperidine hydrochloride (37.7 g) as a white solid.

후처리

  1. customwas removed under reduced pressure
  2. customthe product azeotroped with toluene
  3. customprecipitated out
  4. filtrationfiltered

출처 및 근거

ORD 기록
ord-778ae1da2ae74976806c95bbe1013773
출처 데이터셋
uspto-grants-2003_08
특허 번호
US06610707B1

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