Sodium Iodide → 4-(2-Iodoethyl)-1,1-dimethylcyclohexane
반응식
BrC1C=CC(S(O[CH2:12][CH2:13][CH:14]2[CH2:19][CH2:18][C:17]([CH3:21])([CH3:20])[CH2:16][CH2:15]2)(=O)=O)=CC=1.[I-:22].[Na+]>CC(C)=O>[I:22][CH2:12][CH2:13][CH:14]1[CH2:19][CH2:18][C:17]([CH3:21])([CH3:20])[CH2:16][CH2:15]1참가 물질
4
실험 절차
To a solution of 2-(4,4-dimethylcyclohexyl)ethyl 4-bromobenzenesulfonate (Preparation 16, 410 mg, 1 mmol) in acetone (100 ml) was added sodium iodide (370 mg, 2.5 mmol), and the mixture was heated under reflux for 3 h. After allowing the reaction mixture to cool to room temperature, the mixture was filtered and the filtrate was diluted with water (500 ml) and extracted with diethyl ether (500 ml). The organic extract was dried (MgSO4), filtered and concentrated in vacuo to afford the title compound as a colourless oil (220 mg, 83%).
후처리
- temperaturethe mixture was heated
- temperatureunder reflux for 3 h
- filtrationthe mixture was filtered
- additionthe filtrate was diluted with water (500 ml)
- extractionextracted with diethyl ether (500 ml)
- extractionThe organic extract
- dry with materialwas dried (MgSO4)
- filtrationfiltered
- concentrationconcentrated in vacuo
출처 및 근거
- ORD 기록
- ord-325b46b2db94438d98754737fb9390a0
- 출처 데이터셋
- uspto-grants-2003_08
- 특허 번호
- US06610711B2
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