Sulfuric Acid → 4-(Bromomethyl)benzamide

반응식

[Br:1][CH2:2][C:3]1[CH:10]=[CH:9][C:6]([C:7]#[N:8])=[CH:5][CH:4]=1.S(=O)(=O)(O)[OH:12]>>[Br:1][CH2:2][C:3]1[CH:10]=[CH:9][C:6]([C:7]([NH2:8])=[O:12])=[CH:5][CH:4]=1

참가 물질

반응물 2

HCID 1118Sulfuric Acid

HCID 869964-(Bromomethyl)benzonitrile

생성물 1

HCID 5842164-(Bromomethyl)benzamide수율 65%

실험 절차

A solution of 4-(bromomethyl)benzonitrile (500 mg, 2.55 mmol) in 90% sulphuric acid (8 ml) was heated at 100° C. for 1 h. The solution was carefully poured onto ice water (50 ml) and a precipitate formed. The solid was filtered, washed with water and diethyl ether and dried in vacuo to afford the title compound as a white solid (353 mg, 65%).

후처리

additionThe solution was carefully poured onto ice water (50 ml)
customa precipitate formed
filtrationThe solid was filtered
washwashed with water and diethyl ether
customdried in vacuo

출처 및 근거

ORD 기록: ord-a547e8c3f82245a996fa8c4b3daf857d
출처 데이터셋: uspto-grants-2003_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06610711B2

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