3-Bromo-5-(2-methyl-imidazol-1-ylmethyl)-pyridine → 3-(3-Chloro-4-methyl-phenyl)-5-(2-methyl-imidazol-1-yl-methyl)-pyridine hydrochloride

반응식

Br[C:2]1[CH:3]=[N:4][CH:5]=[C:6]([CH2:8][N:9]2[CH:13]=[CH:12][N:11]=[C:10]2[CH3:14])[CH:7]=1.[Cl:15][C:16]1[CH:17]=[C:18](B2OC(C)(C)C(C)(C)O2)[CH:19]=[CH:20][C:21]=1[CH3:22]>>[ClH:15].[Cl:15][C:16]1[CH:17]=[C:18]([C:2]2[CH:3]=[N:4][CH:5]=[C:6]([CH2:8][N:9]3[CH:13]=[CH:12][N:11]=[C:10]3[CH3:14])[CH:7]=2)[CH:19]=[CH:20][C:21]=1[CH3:22]

참가 물질

반응물 2

HCID 234449653-Bromo-5-(2-methyl-imidazol-1-ylmethyl)-pyridine

HCID 234451072-(3-Chloro-4-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

생성물 1

HCID 234451033-(3-Chloro-4-methyl-phenyl)-5-(2-methyl-imidazol-1-yl-methyl)-pyridine hydrochloride

실험 절차

The title compound, MS: m/e=298.3 (M+H+) was obtained as a beige solid (78% yield) by the reaction of 3-bromo-5-(2-methyl-imidazol-1-yl-methyl)-pyridine with 2-(3-chloro-4-methyl-phenyl)-4,4,5,5-tetramethyl [1,3,2]-dioxaborolane.

출처 및 근거

ORD 기록: ord-becdd11eb89a4865b553e1896a7cba81
출처 데이터셋: uspto-grants-2003_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06610723B2

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