Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetic Acid → HCID 23445088, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetic Acid | HCID 176 | — |
| 반응물 | Ethyl orthoformate | HCID 31214 | — |
| 반응물 | Ethyl nitroacetate | HCID 69379 | — |
| 반응물 | 5-Amino-2,2-difluoro-1,3-benzodioxole | HCID 2736893 | — |
| 촉매 | Iron | HCID 23925 | — |
| 생성물 | HCID 23445088 | HCID 23445088 | — |
반응 단계
Following the general method described in example 293, 2,2-difluoro-benzo[1,3]dioxol-5-ylamine was reacted with triethyl orthoformate, ethyl nitroacetate and acetic acid followed by treatment with triethyl orthoformate, iron and acetic acid and subsequent alkaline hydrolysis. The isolated acid was directly reduced according to example 264, by reaction with BH3 THF complex followed by hydrolytic workup and the title compound was obtained as a light brown solid. Mp. 163-164° C. (H2O), MS: m/e=254 (M+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06610723B2 |
| 출처 데이터셋 | uspto-grants-2003_08 |
| ORD ID | ord-65ecd3d8357344cfb9ddc7bccd520302 |
| 출처 메모 | uspto-grants-2003_08 |