Acetic Acid → HCID 23445088, 화합물

HRID 397936

반응식

HRID 397936 반응식
[F:1][C:2]1([F:12])[O:6][C:5]2[CH:7]=[CH:8][C:9]([NH2:11])=[CH:10][C:4]=2[O:3]1.C([O:20][CH2:21][CH3:22])(OCC)OCC.[N+:23]([CH2:26]C(OCC)=O)([O-])=O.[C:32](O)(=O)C>[Fe]>[F:12][C:2]1([F:1])[O:6][C:5]2[CH:7]=[CH:8][C:9]([N:11]3[CH:32]=[C:22]([CH2:21][OH:20])[N:23]=[CH:26]3)=[CH:10][C:4]=2[O:3]1

참가 물질

6

반응물 4

HCID 176Acetic Acid2회HCID 31214Ethyl orthoformate2회HCID 69379Ethyl nitroacetateHCID 27368935-Amino-2,2-difluoro-1,3-benzodioxole

생성물 1

HCID 23445088HCID 23445088, 화합물

시약·촉매·용매 1

HCID 23925Iron촉매

실험 절차

Following the general method described in example 293, 2,2-difluoro-benzo[1,3]dioxol-5-ylamine was reacted with triethyl orthoformate, ethyl nitroacetate and acetic acid followed by treatment with triethyl orthoformate, iron and acetic acid and subsequent alkaline hydrolysis. The isolated acid was directly reduced according to example 264, by reaction with BH3 THF complex followed by hydrolytic workup and the title compound was obtained as a light brown solid. Mp. 163-164° C. (H2O), MS: m/e=254 (M+).

후처리

  1. customThe isolated acid was directly reduced according to example 264, by reaction with BH3 THF complex

출처 및 근거

ORD 기록
ord-65ecd3d8357344cfb9ddc7bccd520302
출처 데이터셋
uspto-grants-2003_08
특허 번호
US06610723B2

연결된 노트

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