Dimethyl Sulfoxide → (2r,3r,4s,5s)-2-{6-(1-Ethyl-propylamino)-2-[2-(1-methyl-1h-imidazol-4-yl)-ethylamino]-purin-9-yl}-5-(3-methyl-[1,2,4]oxadiazol-5-yl)-tetrahydro-furan-3,4-diol formate

참여 물질

역할	이름	HCID	투입량
반응물	Dimethyl Sulfoxide	HCID 679	—
반응물	1-Methylhistamine	HCID 3614	—
반응물	(2r,3r,4s,5s)-2-[2-Chloro-6-(1-ethyl-propylamino)-purin-9-yl]-5-(3-methyl-[1,2,4]oxadiazol-5-yl)-tetrahydro-furan-3,4-diol	HCID 56619484	—
생성물	(2r,3r,4s,5s)-2-{6-(1-Ethyl-propylamino)-2-[2-(1-methyl-1h-imidazol-4-yl)-ethylamino]-purin-9-yl}-5-(3-methyl-[1,2,4]oxadiazol-5-yl)-tetrahydro-furan-3,4-diol formate	HCID 70021795	—

반응 조건

온도	92.5 °C

반응 단계

Intermediate 11 (0.069 g, 0.163 mmol) and 2-(1-methyl-1H-imidazol-4-yl)ethylamine (0.102 g, 0.815 mmol) were dissolved in DMSO (0.03 ml) and heated at 85-100° C. under nitrogen for 7 days, a further portion of 2-(1-methyl-1H-imidazol-4-yl)ethylamine (0.102 g, 0.815 mmol) was added after the first 5 days. The product was purified by Autoprep. HPLC to give the title compound after freeze drying as a beige solid (0.013 g). LC/MS system A Rt=3.32 min, m/z=512MH+.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US06610665B1
출처 데이터셋	uspto-grants-2003_08
ORD ID	ord-244625160b4e40a991a77878940c609c
출처 메모	uspto-grants-2003_08