2,4-Di-tert-butylphenol → 2-Bromo-4,6-di-tert-butylphenol

HRID 398068노트

반응식

HRID 398068 반응식
[C:1]([C:5]1[CH:10]=[C:9]([C:11]([CH3:14])([CH3:13])[CH3:12])[CH:8]=[CH:7][C:6]=1[OH:15])([CH3:4])([CH3:3])[CH3:2].[Br:16]Br>CC(O)=O>[Br:16][C:7]1[CH:8]=[C:9]([C:11]([CH3:14])([CH3:13])[CH3:12])[CH:10]=[C:5]([C:1]([CH3:4])([CH3:3])[CH3:2])[C:6]=1[OH:15]

참가 물질

4

반응물 2

HCID 73112,4-Di-tert-butylphenolHCID 24408Bromine

생성물 1

HCID 5198222-Bromo-4,6-di-tert-butylphenol수율 91.8%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

To a solution of 2,4-di-t-butylphenol (Aldrich, 2.0 g, 9.7 mmol) in 2 ml of HOAc was added Br2 (0.5 ml, 9.7 mmol). The reaction mixture was stirred at room temperature for 12 hours. Solvent was removed under reduced pressure and the residue was purified by column chromatography (ethyl acetate/hexane 1/20) to yield the desired product (2.54 g) as a white solid. 1H NMR δ7.33 (d, J=2.3 Hz, 1H), 7.24 (d, J=2.3 Hz, 1H), 1.41 (s, 9H), 1.29 (s, 9H).

후처리

  1. customSolvent was removed under reduced pressure
  2. customthe residue was purified by column chromatography (ethyl acetate/hexane 1/20)

출처 및 근거

ORD 기록
ord-e9321be272664a6289d41b9f2ad2a541
출처 데이터셋
uspto-grants-2003_08
특허 번호
US06610744B2

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