Triethylamine → HCID 23000170, 화합물

HRID 398366노트

반응식

HRID 398366 반응식
[CH:1]1([CH2:4][CH2:5][CH2:6][CH2:7][OH:8])[CH2:3][CH2:2]1.C(N(CC)CC)C.[CH3:16][S:17](Cl)(=[O:19])=[O:18]>C(Cl)Cl>[CH3:16][S:17]([O:8][CH2:7][CH2:6][CH2:5][CH2:4][CH:1]1[CH2:3][CH2:2]1)(=[O:19])=[O:18]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 230002214-Cyclopropylbutan-1-ol

생성물 1

HCID 23000170HCID 23000170, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

To a stirred 0° C. solution of 683 mg (6.0 mmol) of 4-cyclopropylbutanol and 1.25 mL (9.0 mmol) of triethylamine in 10 mL of CH2Cl2 was added 697 μL (9.0 mmol) of methanesulfonyl chloride dropwise under Ar. The cold bath was allowed to expire over a 2 h period at which time the reaction mixture was diluted with CH2Cl2, washed with cold 1M HCl, water, sat. NaHCO3, brine, dried over MgSO4 and the solvents removed to give the title compound as a yellow oil:

후처리

  1. washwashed with cold 1M HCl, water, sat. NaHCO3, brine
  2. dry with materialdried over MgSO4
  3. customthe solvents removed

출처 및 근거

ORD 기록
ord-ffeb22255aad496b8c70f40a043f0a49
출처 데이터셋
uspto-grants-2003_08
특허 번호
US06610692B1

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