참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | Sulfuric Acid | HCID 1118 | — |
| 반응물 | 3-Fluoro-4-hydroxybenzeneacetic acid | HCID 68014 | — |
| 생성물 | Methyl 2-(3-fluoro-4-hydroxyphenyl)acetate | HCID 10797559 | 97.6% |
반응 단계
A solution of (3-fluoro-4-hydroxy-phenyl)-acetic acid (1.0 g, 5.87 mmol) in methanol (20 mL) was treated with a catalytic amount of sulfuric acid. The reaction was heated at 120° C. for 6 h. At this time, the reaction was concentrated in vacuo. Flash chromatography (Merck Silica gel 60, 230-400 mesh, 50/50 hexanes/ethyl acetate) afforded (3-fluoro-4-hydroxy-phenyl)-acetic acid methyl ester (1.05 g, 97.6%) as a white solid: mp 34-36° C.: EI-HRMS m/e calcd for C9H9FO3 (M+) 184.0535, found 184.0533.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06610846B1 |
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| 출처 데이터셋 | uspto-grants-2003_08 |
|---|
| ORD ID | ord-dc28b82ec0634ae9918a4b6be6f07d5e |
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| 출처 메모 | uspto-grants-2003_08 |
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