Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diethyl Carbonate → 4-Ethyl-4-hydroxymethyl-2-oxazolidinone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diethyl Carbonate | HCID 7766 | — |
| 반응물 | 2-Amino-2-ethyl-1,3-propanediol | HCID 8282 | — |
| 촉매 | Sodium Methoxide | HCID 10942334 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 4-Ethyl-4-hydroxymethyl-2-oxazolidinone | HCID 11263559 | 66.5% |
반응 단계
Sodium methoxide (2.2 g, Aldrich) was added to a solution of 2-amino-2-ethyl-1,3-propanediol(100.0 g, Aldrich) and diethyl carbonate (169.0 g, Aldrich) This solution was refluxed in a Dean Stark apparatus until no more EtOH was collected. The reaction mixture was cooled, added acetone(200 ml) and allowed to stand overnite at room temperature. The resulting suspension was filtered to give 81.0 g of the desired product as a beige solid. 1H NMR consistent with the proposed structure.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05817652 |
| 출처 데이터셋 | uspto-grants-1998_10 |
| ORD ID | ord-58e4b581318740f5b42cfeb857ddca99 |
| 출처 메모 | uspto-grants-1998_10 |