2-Bromobenzenethiol → (+/-)-1-(((2-Bromophenyl)thio)methyl)-1-ethylpentanamine

HRID 398818노트

반응식

HRID 398818 반응식
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[SH:8].[CH2:9]([C:13]1([CH2:16][CH3:17])[CH2:15][NH:14]1)[CH2:10][CH2:11][CH3:12]>CO>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8][CH2:15][C:13]([CH2:16][CH3:17])([NH2:14])[CH2:9][CH2:10][CH2:11][CH3:12]

참가 물질

4

반응물 2

HCID 805982-BromobenzenethiolHCID 217099702-Butyl-2-ethylaziridine

생성물 1

HCID 18968814(+/-)-1-(((2-Bromophenyl)thio)methyl)-1-ethylpentanamine수율 113.4%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of 2-bromothiophenol (13.5 g, Lancaster) in methanol (45 ml) was added dropwise 2-butyl-2-ethylaziridine (10.0 g, Synthetic Example 1(f)). The mixture was stirred at room temperature for 1 hour. Solvent was evaporated to afford the title product as a light yellow oil (25.6 g). 1H NMR consistent with the proposed structure.

후처리

  1. customSolvent was evaporated

출처 및 근거

ORD 기록
ord-54b6725a54c643498ef18e10b19f3721
출처 데이터셋
uspto-grants-1998_10
특허 번호
US05817652

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