Methyl chloroacetate → HCID 18969559, 화합물

HRID 399017

반응식

HRID 399017 반응식
[OH:1][C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[CH:7][NH:8]2)=[CH:4][CH:3]=1.Cl[CH2:12][C:13]([O:15][CH3:16])=[O:14].C(=O)([O-])[O-].[K+].[K+]>[I-].[K+].CC(C)=O>[CH3:16][O:15][C:13]([CH2:12][O:1][C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[CH:7][NH:8]2)=[CH:4][CH:3]=1)=[O:14]

참가 물질

6

반응물 3

HCID 7295Methyl chloroacetateHCID 11430Potassium CarbonateHCID 5245086-Hydroxyindole

생성물 1

HCID 18969559HCID 18969559, 화합물수율 63.3%

시약·촉매·용매 2

HCID 4875Potassium Iodide촉매HCID 180Acetone용매

실험 절차

6-Hydroxyindole (2.9 g), methyl chloroacetate (2.7 g), potassium carbonate (5.5 g) and potassium iodide (0.2 g) are added to acetone (100 ml), and the mixture is refluxed for 8 hours. The reaction mixture is cooled to room temperature, and the insoluble materials are removed by filtration. The filtrate is evaporated under reduced pressure. The residue is purified by silica gel column chromatography (eluent; chloroform) to give 6-methoxycarbonylmethoxyindole (2.83 g).

후처리

  1. temperaturethe mixture is refluxed for 8 hours
  2. customthe insoluble materials are removed by filtration
  3. customThe filtrate is evaporated under reduced pressure
  4. customThe residue is purified by silica gel column chromatography (eluent; chloroform)

출처 및 근거

ORD 기록
ord-59f19f98a90542538f9d78d9b52ab590
출처 데이터셋
uspto-grants-1998_10
특허 번호
US05817689

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