Methyl chloroacetate → (1H-Indol-6-yloxy)-acetic acid methyl ester
반응식
[OH:1][C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[CH:7][NH:8]2)=[CH:4][CH:3]=1.Cl[CH2:12][C:13]([O:15][CH3:16])=[O:14].C(=O)([O-])[O-].[K+].[K+]>[I-].[K+].CC(C)=O>[CH3:16][O:15][C:13]([CH2:12][O:1][C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[CH:7][NH:8]2)=[CH:4][CH:3]=1)=[O:14]참가 물질
6
실험 절차
6-Hydroxyindole (2.9 g), methyl chloroacetate (2.7 g), potassium carbonate (5.5 g) and potassium iodide (0.2 g) are added to acetone (100 ml), and the mixture is refluxed for 8 hours. The reaction mixture is cooled to room temperature, and the insoluble materials are removed by filtration. The filtrate is evaporated under reduced pressure. The residue is purified by silica gel column chromatography (eluent; chloroform) to give 6-methoxycarbonylmethoxyindole (2.83 g).
후처리
- temperaturethe mixture is refluxed for 8 hours
- customthe insoluble materials are removed by filtration
- customThe filtrate is evaporated under reduced pressure
- customThe residue is purified by silica gel column chromatography (eluent; chloroform)
출처 및 근거
- ORD 기록
- ord-59f19f98a90542538f9d78d9b52ab590
- 출처 데이터셋
- uspto-grants-1998_10
- 특허 번호
- US05817689
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