Iodine → HCID 12786936, 화합물

HRID 399143노트

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HRID 399143 반응식
[C:1]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([Br:10])[N:5]=1)(=[O:3])[CH3:2].[I:11]I>N1C=CC=CC=1>[I-:11].[Br:10][C:6]1[N:5]=[C:4]([C:1](=[O:3])[CH2:2][N+:5]2[CH:6]=[CH:7][CH:8]=[CH:9][CH:4]=2)[CH:9]=[CH:8][CH:7]=1

참가 물질

4

반응물 2

HCID 807IodineHCID 112985782-Acetyl-6-bromopyridine

생성물 1

HCID 12786936HCID 12786936, 화합물수율 167.9%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

A mixture of 2-acetyl-6-bromopyridine (0.075 mol), 25 ml of pyridine, and iodine (0.075 mol) was allowed to react at 100° C. for 45 minutes and then cooled to room temperature. The reaction mixture was filtered, the solid product was triturated with CH2Cl2 (200 ml), isolated by filtration, and the residual solvent was removed under vacuum to yield 25.5 g (85%) of the desired salt. Melting point: 176°-178° C.

후처리

  1. customto react at 100° C. for 45 minutes
  2. filtrationThe reaction mixture was filtered
  3. customthe solid product was triturated with CH2Cl2 (200 ml)
  4. customisolated by filtration
  5. customthe residual solvent was removed under vacuum

출처 및 근거

ORD 기록
ord-a776590251bf4765b63bab6d99fdbaaf
출처 데이터셋
uspto-grants-1998_10
특허 번호
US05817774

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