Thionyl Chloride → 3-Chloro-1-methyl-1h-pyrazole-5-carbonyl chloride

HRID 399191

반응식

HRID 399191 반응식
[Cl:1][C:2]1[CH:6]=[C:5]([C:7](O)=[O:8])[N:4]([CH3:10])[N:3]=1.S(Cl)([Cl:13])=O>C1C=CC=CC=1>[Cl:1][C:2]1[CH:6]=[C:5]([C:7]([Cl:13])=[O:8])[N:4]([CH3:10])[N:3]=1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 189704593-chloro-1-methyl-1H-pyrazole-5-carboxylic acid

생성물 1

HCID 189704623-Chloro-1-methyl-1h-pyrazole-5-carbonyl chloride

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

100 g of 3-chloro-1-methyl-5-pyrazole-carboxylic acid (the Compound No. 4.1 (a) of the present invention) were suspended in 200 ml of benzene, and 150 ml of thionyl chloride were added thereto dropwise. Then, the mixture was heat-refluxed for 4 hours. The reaction mixture was allowed to cool, and the solvent was then distilled off under reduced pressure. The resulting residue was distilled under reduced pressure to obtain 103 g of the intended 3-chloro-1-methyl-5-pyrazolecarbonyl chloride.

후처리

  1. temperatureThen, the mixture was heat-refluxed for 4 hours
  2. temperatureto cool
  3. distillationthe solvent was then distilled off under reduced pressure
  4. distillationThe resulting residue was distilled under reduced pressure

출처 및 근거

ORD 기록
ord-14124bb4c18a40d087add9a7a5ae0295
출처 데이터셋
uspto-grants-1998_10
특허 번호
US05817829

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