2-(2-Dimethylaminoethoxy)-4-nitroanisole → 3-(2-(Dimethylamino)ethoxy)-4-methoxyaniline

HRID 399268노트

반응식

HRID 399268 반응식
[CH3:1][N:2]([CH3:17])[CH2:3][CH2:4][O:5][C:6]1[CH:11]=[C:10]([N+:12]([O-])=O)[CH:9]=[CH:8][C:7]=1[O:15][CH3:16]>C(O)C.[Pd]>[CH3:1][N:2]([CH3:17])[CH2:3][CH2:4][O:5][C:6]1[CH:11]=[C:10]([CH:9]=[CH:8][C:7]=1[O:15][CH3:16])[NH2:12]

참가 물질

4

반응물 1

HCID 107764242-(2-Dimethylaminoethoxy)-4-nitroanisole

생성물 1

HCID 105603983-(2-(Dimethylamino)ethoxy)-4-methoxyaniline수율 100%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

A solution of 2-(2-dimethylaminoethoxy)-4-nitroanisole (D10, 11.8 g, 0.049 mole) in ethanol (200 ml) was hydrogenated over 10% Pd-C (1 g) at atmospheric temperature and pressure. The catalyst was filtered off through kieselguhr and the filtrate concentrated in vacuo to afford the title compound as a beige solid (10.3 g, 100%).

후처리

  1. filtrationThe catalyst was filtered off through kieselguhr
  2. concentrationthe filtrate concentrated in vacuo

출처 및 근거

ORD 기록
ord-9fa44c1a12b4477088e773850b35097d
출처 데이터셋
uspto-grants-1998_10
특허 번호
US05817833

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