4-Chloro-6,7-dimethoxyquinazoline hydrochloride → 4-(3-Chloro-4-phenylthioanilino)-6,7-dimethoxyquinazoline hydrochloride salt

HRID 399460노트

반응식

HRID 399460 반응식
[C:1]1([S:7][C:8]2[CH:13]=[CH:12][C:11]([NH2:14])=[CH:10][C:9]=2[Cl:15])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.Cl[C:18]1[C:27]2[C:22](=[CH:23][C:24]([O:30][CH3:31])=[C:25]([O:28][CH3:29])[CH:26]=2)[N:21]=[CH:20][N:19]=1>>[ClH:15].[Cl:15][C:9]1[CH:10]=[C:11]([CH:12]=[CH:13][C:8]=1[S:7][C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)[NH:14][C:18]1[C:27]2[C:22](=[CH:23][C:24]([O:30][CH3:31])=[C:25]([O:28][CH3:29])[CH:26]=2)[N:21]=[CH:20][N:19]=1

참가 물질

3

반응물 2

HCID 220221614-Chloro-6,7-dimethoxyquinazoline hydrochlorideHCID 234380833-Chloro-4-(phenylsulfanyl)aniline

생성물 1

HCID 189675804-(3-Chloro-4-phenylthioanilino)-6,7-dimethoxyquinazoline hydrochloride salt수율 71%

실험 절차

Using an analogous procedure to that described in Example 1 except that the reaction mixture was heated to reflux for 16 hours, 4-amino-2-chlorophenyl phenyl sulphide was reacted with 4-chloro-6,7-dimethoxyquinazoline hydrochloride to give 4-(3-chloro-4-phenylthioanilino)-6,7-dimethoxyquinazoline hydrochloride salt in 71% yield, m.p. 245°-247° C.;

후처리

  1. temperaturewas heated
  2. temperatureto reflux for 16 hours

출처 및 근거

ORD 기록
ord-a4623f041c024e92b04b6745d0f11b39
출처 데이터셋
uspto-grants-1998_10
특허 번호
US05821246

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