3-chloro-4-(1-methyl-1H-imidazol-2-ylsulfanyl)phenylamine → 4-[3-Chloro-4-(1-methylimidazol-2-ylthio)anilino]-6,7-dimethoxyquinazoline dihydrochloride salt

HRID 399461노트

반응식

HRID 399461 반응식
[CH3:1][N:2]1[CH:6]=[CH:5][N:4]=[C:3]1[S:7][C:8]1[CH:13]=[CH:12][C:11]([NH2:14])=[CH:10][C:9]=1[Cl:15].Cl.[Cl:17][C:18]1[C:27]2[C:22](=[CH:23][C:24]([O:30][CH3:31])=[C:25]([O:28][CH3:29])[CH:26]=2)[N:21]=[CH:20][N:19]=1>>[ClH:15].[ClH:17].[Cl:15][C:9]1[CH:10]=[C:11]([CH:12]=[CH:13][C:8]=1[S:7][C:3]1[N:2]([CH3:1])[CH:6]=[CH:5][N:4]=1)[NH:14][C:18]1[C:27]2[C:22](=[CH:23][C:24]([O:30][CH3:31])=[C:25]([O:28][CH3:29])[CH:26]=2)[N:21]=[CH:20][N:19]=1

참가 물질

3

반응물 2

HCID 114590883-chloro-4-(1-methyl-1H-imidazol-2-ylsulfanyl)phenylamineHCID 220221614-Chloro-6,7-dimethoxyquinazoline hydrochloride

생성물 1

HCID 189675744-[3-Chloro-4-(1-methylimidazol-2-ylthio)anilino]-6,7-dimethoxyquinazoline dihydrochloride salt수율 71%

실험 절차

Using an analogous procedure to that described in Example 1 except that the reaction mixture was heated to reflux for 16 hours, 4-amino-2-chlorophenyl 1-methylimidazol-2-yl sulphide was reacted with 4-chloro-6,7-dimethoxyquinazoline hydrochloride to give 4-[3-chloro-4-(1-methylimidazol-2-ylthio)anilino]-6,7-dimethoxyquinazoline dihydrochloride salt in 71% yield, m.p. 244°-246° C.;

후처리

  1. temperaturewas heated
  2. temperatureto reflux for 16 hours

출처 및 근거

ORD 기록
ord-f5a619faf5fd4a83a1d88bbabdb84d58
출처 데이터셋
uspto-grants-1998_10
특허 번호
US05821246

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