Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Chloro-6,7-dimethoxyquinazoline hydrochloride → 6,7-Dimethoxy-4-[3-methyl-4-(2-pyridylmethoxy)anilino]quinazoline dihydrochloride salt
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Chloro-6,7-dimethoxyquinazoline hydrochloride | HCID 22022161 | — |
| 반응물 | 3-Methyl-4-(pyridin-2-ylmethoxy)aniline | HCID 23438288 | — |
| 생성물 | 6,7-Dimethoxy-4-[3-methyl-4-(2-pyridylmethoxy)anilino]quinazoline dihydrochloride salt | HCID 18967633 | 60% |
반응 단계
Using an analogous procedure to that described in Example 1, 5-amino-2-tolyl 2-pyridylmethyl ether was reacted with 4-chloro-6,7-dimethoxyquinazoline hydrochloride to give 6,7-dimethoxy-4-[3-methyl-4-(2-pyridylmethoxy)anilino]quinazoline dihydrochloride salt in 60% yield, m.p. 239°-241° C.;
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05821246 |
| 출처 데이터셋 | uspto-grants-1998_10 |
| ORD ID | ord-f8567c0c0aa34bd9a8d0375068c3889a |
| 출처 메모 | uspto-grants-1998_10 |