2-Thiocresol → 2-Chloro-4-nitrophenyl 2-tolyl sulphide

반응식

[Cl:1][C:2]1[CH:3]=[C:4]([N+:9]([O-:11])=[O:10])[CH:5]=[CH:6][C:7]=1F.[C:12]1([CH3:19])[C:13]([SH:18])=[CH:14][CH:15]=[CH:16][CH:17]=1>>[C:12]1([CH3:19])[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[S:18][C:7]1[CH:6]=[CH:5][C:4]([N+:9]([O-:11])=[O:10])=[CH:3][C:2]=1[Cl:1]

참가 물질

반응물 2

HCID 87122-Thiocresol

HCID 676882-Chloro-1-fluoro-4-nitrobenzene

생성물 1

HCID 189676862-Chloro-4-nitrophenyl 2-tolyl sulphide수율 31%

실험 절차

Using an analogous procedure to that described in the first paragraph of the portion of Example 8 which is concerned with the preparation of starting materials, 3-chloro-4-fluoronitrobenzene was reacted with 2-toluenethiol. The reaction mixture was partitioned between ethyl acetate and water. The organic phase was dried (MgSO4) and evaporated to give 2-chloro-4-nitrophenyl 2-tolyl sulphide in 31% yield.

후처리

customThe reaction mixture was partitioned between ethyl acetate and water
dry with materialThe organic phase was dried (MgSO4)
customevaporated

출처 및 근거

ORD 기록: ord-07809e61d2f446198d2040d80c3b8ad1
출처 데이터셋: uspto-grants-1998_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05821246

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