2-Chloro-1-fluoro-4-nitrobenzene → 3-Chloro-4-(2-thiazolylthio)nitrobenzene

반응식

[Cl:1][C:2]1[CH:3]=[C:4]([N+:9]([O-:11])=[O:10])[CH:5]=[CH:6][C:7]=1F.[S:12]1[CH:16]=[CH:15][N:14]=[C:13]1[SH:17]>>[S:12]1[CH:16]=[CH:15][N:14]=[C:13]1[S:17][C:7]1[CH:6]=[CH:5][C:4]([N+:9]([O-:11])=[O:10])=[CH:3][C:2]=1[Cl:1]

참가 물질

반응물 2

HCID 676882-Chloro-1-fluoro-4-nitrobenzene

HCID 178527881HCID 178527881, 화합물

생성물 1

HCID 189676023-Chloro-4-(2-thiazolylthio)nitrobenzene수율 26%

실험 절차

Using an analogous procedure to that described in the first paragraph of the portion of Example 8 which is concerned with the preparation of starting materials, 3-chloro-4-fluoronitrobenzene was reacted with 2-thiazolethiol to give a precipitated solid which was partitioned between ethyl acetate and water. The organic phase was dried (MgSO4) and evaporated to give 2-chloro-4-nitrophenyl 2-thiazolyl sulphide in 26% yield.

후처리

customto give a precipitated solid which
customwas partitioned between ethyl acetate and water
dry with materialThe organic phase was dried (MgSO4)
customevaporated

출처 및 근거

ORD 기록: ord-ef581cff486446fe8604b1eb80db8312
출처 데이터셋: uspto-grants-1998_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05821246

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