Hydrogen chloride-ethyl acetate → 1-(2-(4-(4-ethylbenzylamino)piperidin-1-yl)ethyl)-7-methoxy-N-methyl-2-oxo-1,2-dihydroquinoline-4-carboxamide hydrochloride

HRID 39952

반응식

HRID 39952 반응식
[CH2:1]([C:3]1[CH:35]=[CH:34][C:6]([CH2:7][NH:8][CH:9]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][N:17]3[C:26]4[C:21](=[CH:22][CH:23]=[C:24]([O:27][CH3:28])[CH:25]=4)[C:20]([C:29]([NH:31][CH3:32])=[O:30])=[CH:19][C:18]3=[O:33])[CH2:11][CH2:10]2)=[CH:5][CH:4]=1)[CH3:2].[ClH:36].C(OCC)(=O)C>CO>[ClH:36].[CH2:1]([C:3]1[CH:35]=[CH:34][C:6]([CH2:7][NH:8][CH:9]2[CH2:10][CH2:11][N:12]([CH2:15][CH2:16][N:17]3[C:26]4[C:21](=[CH:22][CH:23]=[C:24]([O:27][CH3:28])[CH:25]=4)[C:20]([C:29]([NH:31][CH3:32])=[O:30])=[CH:19][C:18]3=[O:33])[CH2:13][CH2:14]2)=[CH:5][CH:4]=1)[CH3:2]

참가 물질

4

반응물 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 593980151-(2-(4-(4-ethylbenzylamino)piperidin-1-yl)ethyl)-7-methoxy-N-methyl-2-oxo-1,2-dihydroquinoline-4-carboxamide

생성물 1

HCID 675376111-(2-(4-(4-ethylbenzylamino)piperidin-1-yl)ethyl)-7-methoxy-N-methyl-2-oxo-1,2-dihydroquinoline-4-carboxamide hydrochloride

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To 2 mL of a methanol solution containing 0.14 g of 1-(2-(4-(4-ethylbenzylamino)piperidin-1-yl)ethyl)-7-methoxy-N-methyl-2-oxo-1,2-dihydroquinoline-4-carboxamide, 1 mL of 4 mol/L hydrogen chloride/ethyl acetate was added at room temperature, and the solvent was removed under reduced pressure. Ethyl acetate was added to the residue thus obtained, and the resulting solid was filtered to give 0.15 g of 1-(2-(4-(4-ethylbenzylamino)piperidin-1-yl)ethyl)-7-methoxy-N-methyl-2-oxo-1,2-dihydroquinoline-4-carboxamide hydrochloride as a pale yellow solid.

후처리

  1. additionwas added at room temperature
  2. customthe solvent was removed under reduced pressure
  3. additionEthyl acetate was added to the residue
  4. customthus obtained
  5. filtrationthe resulting solid was filtered

출처 및 근거

ORD 기록
ord-4e3a52c7dc1144b5993f9b39d3a77104
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08524738B2

연결된 노트

불러오는 중…