Piperazine → HCID 131718840, 화합물

HRID 399733

반응식

HRID 399733 반응식
[C:1]([NH:4][C@H:5]([C:18]([OH:20])=[O:19])[CH2:6][S:7][S:8][CH2:9][C@H:10]([NH:14][C:15](=[O:17])[CH3:16])[C:11]([OH:13])=[O:12])(=[O:3])[CH3:2].[NH:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1>O>[NH2+:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1.[C:15]([NH:14][C@H:10]([C:11]([O-:13])=[O:12])[CH2:9][S:8][S:7][CH2:6][C@H:5]([NH:4][C:1](=[O:3])[CH3:2])[C:18]([O-:20])=[O:19])(=[O:17])[CH3:16]

참가 물질

4

반응물 2

HCID 4837PiperazineHCID 6995101N,N'-Diacetyl-L-cystine

생성물 1

HCID 131718840HCID 131718840, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To N,N'-diacetyl-L-cystine (4.60 mmole, 1.49 g) dissolved in 5 mL of water was added piperazine (4.60 mmole, 0.90 g). To the solution was added enough isopropanole to cause formation of an oil, which slowly solidifies. The salt was isolated and dried. Physical data: Mp >170° C. (dec.) 1H-NMR (D2O) δ: 2.05 [6H,s,CH3 ], 2.96 [2H,dd,CH2S], 3.26 [2H,dd,CH2S], 3.42 [8H,s,CH2 (2,3,5,6)], 4.49 [2H,dd,CHN]

후처리

  1. additionTo the solution was added enough isopropanole
  2. customThe salt was isolated
  3. customdried

출처 및 근거

ORD 기록
ord-d8e32015c1a74521bdc6954b216fce32
출처 데이터셋
uspto-grants-1998_10
특허 번호
US05824681

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