Jineol → 3,8-Dimethoxy quinoline

HRID 399742

반응식

HRID 399742 반응식
[CH:1]1[CH:10]=[C:9]([OH:11])[C:8]2[N:7]=CC(O)=[CH:4][C:3]=2[CH:2]=1.[N+](=[CH2:15])=[N-].C[CH2:17][O:18][CH2:19][CH3:20]>C(O)C>[CH3:17][O:18][C:19]1[CH:20]=[N:7][C:8]2[C:3]([CH:4]=1)=[CH:2][CH:1]=[CH:10][C:9]=2[O:11][CH3:15]

참가 물질

4

반응물 2

HCID 177338JineolHCID 21186548Diazomethane diethylether

생성물 1

HCID 105837983,8-Dimethoxy quinoline수율 80%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Jineol of 4.5 mg was dissolved in 2 ml of ethanol, and diazomethane ether solution was slowly dropped to the solution. After the excess of diazomethane and solvent was removed by purging with nitrogen gas, the solution was purified by silicagel chromatography to give 4.2 mg of 3,8-dimethoxy quinoline with 80% yield.

후처리

  1. customAfter the excess of diazomethane and solvent was removed
  2. customby purging with nitrogen gas
  3. customthe solution was purified by silicagel chromatography

출처 및 근거

ORD 기록
ord-a3d35d944aca43608a8e9c356519b602
출처 데이터셋
uspto-grants-1998_10
특허 번호
US05824689

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