3-Bromophenylhydrazine hydrochloride → HCID 67613181, 화합물

HRID 399772

반응식

HRID 399772 반응식
Cl.[Br:2][C:3]1[CH:4]=[C:5]([NH:9][NH2:10])[CH:6]=[CH:7][CH:8]=1.[O:11]1[CH:15]=[CH:14][CH2:13][CH2:12]1>C1COCC1>[Br:2][C:3]1[CH:4]=[C:5]([NH:9][N:10]=[CH:15][CH2:14][CH2:13][CH2:12][OH:11])[CH:6]=[CH:7][CH:8]=1

참가 물질

4

반응물 2

HCID 337573-Bromophenylhydrazine hydrochlorideHCID 709342,3-Dihydrofuran

생성물 1

HCID 67613181HCID 67613181, 화합물수율 99.6%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Under anhydrous conditions a solution of 3-bromophenylhydrazine hydrochloride (22.5 g, 100 mmol) and 2,3-dihydrofuran (7.55 ml, 100 mmol) in 200 ml of dry THF was stirred at ambient temperature for 3 h. The reaction mixture was partitioned between EtOAc and H2O. The organic phase was washed with H2O and brine. After drying (Na2 SO4), the solvent was evaporated to give 25.6 g of the product as a brown oil. The product was of suitable purity for use in the next step.

후처리

  1. customThe reaction mixture was partitioned between EtOAc and H2O
  2. washThe organic phase was washed with H2O and brine
  3. customAfter drying (Na2 SO4)
  4. customthe solvent was evaporated

출처 및 근거

ORD 기록
ord-71f44accceb34da08c5f8b2e174c5c94
출처 데이터셋
uspto-grants-1998_10
특허 번호
US05824699

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