Methanol → 2-[3-(2-Cyanopyrrol-1-yl) benzoyl]guanidine hemisulfate

HRID 399871노트

반응식

HRID 399871 반응식
[S:1](=[O:5])(=[O:4])([OH:3])[OH:2].[C:6]([C:8]1[N:9]([C:13]2[CH:14]=[C:15]([CH:22]=[CH:23][CH:24]=2)[C:16]([N:18]=[C:19]([NH2:21])[NH2:20])=[O:17])[CH:10]=[CH:11][CH:12]=1)#[N:7].CO>C(OCC)(=O)C>[S:1]([OH:5])([OH:4])(=[O:3])=[O:2].[C:6]([C:8]1[N:9]([C:13]2[CH:14]=[C:15]([CH:22]=[CH:23][CH:24]=2)[C:16]([N:18]=[C:19]([NH2:20])[NH2:21])=[O:17])[CH:10]=[CH:11][CH:12]=1)#[N:7].[C:6]([C:8]1[N:9]([C:13]2[CH:14]=[C:15]([CH:22]=[CH:23][CH:24]=2)[C:16]([N:18]=[C:19]([NH2:20])[NH2:21])=[O:17])[CH:10]=[CH:11][CH:12]=1)#[N:7]

참가 물질

5

반응물 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 189451892-[3-(2-Cyanopyrrol-1-yl)benzoyl]guanidine

생성물 1

HCID 1317208902-[3-(2-Cyanopyrrol-1-yl) benzoyl]guanidine hemisulfate

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

Conc. sulfuric acid (0.42 ml) was added to a mixture of 2-[3-(2-cyanopyrrol-1-yl)benzoyl]guanidine (2.0 g) and methanol (20 ml), and the mixture was stirred for 30 minutes at ambient temperature. To the mixture was added ethyl acetate (20 ml), and the isolated precipitate was collected by filtration. The precipitate was recrystallized from methanol-water to give 2-[3-(2-cyanopyrrol-1-yl) benzoyl]guanidine hemisulfate (1.53 g).

후처리

  1. filtrationthe isolated precipitate was collected by filtration
  2. customThe precipitate was recrystallized from methanol-water

출처 및 근거

ORD 기록
ord-97023756ec204dcb8260329331a5d280
출처 데이터셋
uspto-grants-1998_10
특허 번호
US05824691

반응 노트

불러오는 중…