Methanesulfonic Acid → 2-[3-(2-Cyanopyrrol-1-yl)benzoyl]guanidine methanesulfonate

HRID 399878노트

반응식

HRID 399878 반응식
[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].[C:6]([C:8]1[N:9]([C:13]2[CH:14]=[C:15]([CH:22]=[CH:23][CH:24]=2)[C:16]([N:18]=[C:19]([NH2:21])[NH2:20])=[O:17])[CH:10]=[CH:11][CH:12]=1)#[N:7].C(OCC)(=O)C>CO>[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].[C:6]([C:8]1[N:9]([C:13]2[CH:14]=[C:15]([CH:22]=[CH:23][CH:24]=2)[C:16]([N:18]=[C:19]([NH2:20])[NH2:21])=[O:17])[CH:10]=[CH:11][CH:12]=1)#[N:7]

참가 물질

5

반응물 3

HCID 6395Methanesulfonic AcidHCID 8857Ethyl AcetateHCID 189451892-[3-(2-Cyanopyrrol-1-yl)benzoyl]guanidine

생성물 1

HCID 867532352-[3-(2-Cyanopyrrol-1-yl)benzoyl]guanidine methanesulfonate

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Methanesulfonic acid (0.8 ml) was added to a mixture of 2-[3-(2-cyanopyrrol-1-yl)benzoyl]guanidine (2.0 g) in methanol (20 ml) and the mixture was stirred for 30 minutes at ambient temperature. To the mixture was added ethyl acetate (20 ml) and isolated precipitate was collected by filtration. The precipitate was recrystallized from water to give 2-[3-(2-cyanopyrrol-1-yl)benzoyl]guanidine methanesulfonate (1.48 g).

후처리

  1. customisolated precipitate
  2. filtrationwas collected by filtration
  3. customThe precipitate was recrystallized from water

출처 및 근거

ORD 기록
ord-4f19722ec46d44dcba0ab3ec1beba662
출처 데이터셋
uspto-grants-1998_10
특허 번호
US05824691

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