Chlorambucil → Indole-3-Acetic Acid

HRID 399883

반응식

HRID 399883 반응식
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[C:2]1CC(O)=O.N1C2C(=CC=CC=2)C(C[CH2:24][C:25]([OH:27])=[O:26])=C1.CC1NC2C(C=1CC(O)=O)=CC=CC=2.C1OC2C=C(CC(O)=O)C=CC=2O1.C1C(/C=C/C(O)=O)=CC2OCOC=2C=1.N1C2C(=CC=CC=2)C(CCCC(O)=O)=C1.COC1C=C2C(=CC=1)NC=C2CC(O)=O.O1C2C(=CC=CC=2CC(O)=O)C(=O)C=C1C1C=CC=CC=1.C1C(CCCC(O)=O)=CC=C(N(CCCl)CCCl)C=1>>[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH2:24][C:25]([OH:27])=[O:26])=[CH:2]1

참가 물질

10

반응물 9

HCID 2708ChlorambucilHCID 37441H-Indole-3-propanoic acidHCID 8617Indole-3-Butyric AcidHCID 189865-Methoxyindoleacetic acidHCID 55748Flavone-8-Acetic AcidHCID 76115Benzo-1,3-dioxole-5-acetic acidHCID 5891072-Methyl-1H-indole-3-acetic acidHCID 6431813,4-Methylenedioxycinnamic acidHCID 43717522-Indolylacetic acid

생성물 1

HCID 802Indole-3-Acetic Acid

실험 절차

2-indolylacetic acid; (N-methyl)-2- or -3-indolylacetic acid; 3-(3-indolyl)propionic acid; 3- or 2-indolylacrylic acid (also (N-methyl)); (2-methyl-3-indolyl)acetic acid, 3,4-(methylenedioxy)phenylacetic acid; 3,4-(methylenedioxy)cinnamic acid; indole-3-butyric acid; (5-methoxyindol-3-yl)acetic acid; naphthyl-1- or -2-acetic acid; flavone-8-acetic acid; 5,6-dimethylxanthone-4-acetic acid (L. L. Thomsen et al.: Cancer Chemother, Pharmacol. 31, 151ff. (1992) demonstrate that the corticoid 21-carboxylic esters prepared from this could also have an antitumorigenic effect, likewise the abovementioned chlorambucil).

후처리

  1. customprepared from

출처 및 근거

ORD 기록
ord-f17162eee9fd4fa2a1cf4cb44ea995ed
출처 데이터셋
uspto-grants-1998_10
특허 번호
US05824670

연결된 노트

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