Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Propanesulfonate → 1-[2-[3-(3,4-Dichloro-phenyl)-1-(3,4,5-trimethoxy-benzoyl)-pyrrolidin-3-yl]-ethyl]-4-phenyl-piperidine-4-carboxylic acid 4-methylpiperazine-amide hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Propanesulfonate | HCID 4431756 | — |
| 반응물 | Ethyl acetate hexane | HCID 21226206 | — |
| 반응물 | 4-Phenyl-piperidine-4-carboxylic acid 4-methylpiperazine-amide hydrochloride | HCID 67562154 | — |
| 반응물 | 2-[1-(3,4,5-Trimethoxy-benzoyl)-3-(3,4-dichloro-phenyl)-pyrrolidin-3-yl]-ethyl-methanesulfonate | HCID 86750906 | — |
| 용매 | Dichloromethane methanol | HCID 21226129 | — |
| 생성물 | 1-[2-[3-(3,4-Dichloro-phenyl)-1-(3,4,5-trimethoxy-benzoyl)-pyrrolidin-3-yl]-ethyl]-4-phenyl-piperidine-4-carboxylic acid 4-methylpiperazine-amide hydrochloride | HCID 67562211 | — |
반응 단계
Prepare by the method of example 27.3.1 using 2-[3-(3,4-dichloro-phenyl)-1-(3,4,5-trimethoxy-benzoyl)-pyrrolidin-3-yl]-ethyl-methanesulfonate (2.8 g, 5.24 mmol) and 4-phenyl-piperidine-4-carboxylic acid 4-methylpiperazine-amide pyrrolidin-3-yl]-ethyl-methanesulfonate (2.8 g, 5.24 mmol) and 4-phenyl-piperidine-4-carboxylic acid 4-methylpiperazine-amide hydrochloride (2.8 g, 3.9 mmol). Chromatograph on silica gel eluting sequentially with 50% ethyl acetate/hexane, 3% methanol/dichloromethane, and then 6% methanol/dichloromethane to give the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05824690 |
| 출처 데이터셋 | uspto-grants-1998_10 |
| ORD ID | ord-c8a52108f6f846b09832c344e0562d86 |
| 출처 메모 | uspto-grants-1998_10 |