HCID 67561638, 화합물 → HCID 131720895, 화합물

반응식

[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([CH2:27][CH2:28]CS([O-])(=O)=O)[CH2:12][CH2:11][N:10]([C:13](=[O:26])[C:14]3[CH:19]=[C:18]([O:20][CH3:21])[C:17]([O:22][CH3:23])=[C:16]([O:24][CH3:25])[CH:15]=3)[CH2:9]2)=[CH:4][CH:3]=1.Cl.[N:35]1([C:41]([NH2:43])=[O:42])[CH2:40][CH2:39][O:38][CH2:37][CH2:36]1.[C:44]1([C:50]2([C:56]([OH:58])=O)[CH2:55][CH2:54][NH:53][CH2:52][CH2:51]2)[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=1>>[N:35]1([C:41]([NH2:43])=[O:42])[CH2:40][CH2:39][O:38][CH2:37][CH2:36]1.[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([CH2:27][CH2:28][N:53]3[CH2:52][CH2:51][C:50]([C:44]4[CH:45]=[CH:46][CH:47]=[CH:48][CH:49]=4)([C:56]([NH2:35])=[O:58])[CH2:55][CH2:54]3)[CH2:12][CH2:11][N:10]([C:13](=[O:26])[C:14]3[CH:19]=[C:18]([O:20][CH3:21])[C:17]([O:22][CH3:23])=[C:16]([O:24][CH3:25])[CH:15]=3)[CH2:9]2)=[CH:4][CH:3]=1

참가 물질

반응물 2

HCID 67561638HCID 67561638, 화합물

HCID 86753248HCID 86753248, 화합물

생성물 1

HCID 131720895HCID 131720895, 화합물

실험 절차

Prepare by the method of example 88.6 using 2-[3-(4-fluoro-phenyl)-1-(3,4,5-trimethoxy-benzoyl)-pyrrolidin-3-yl]-ethyl-methanesulfonate and 4-phenyl-piperidine-4-carboxylic acid morpholine-amide hydrochloride to give the title compound: Rf =0.57 (silica gel, 10% methanol/dichloromethane).

출처 및 근거

ORD 기록: ord-9ecbc9a7b04f46daa58ab94fa0f38dee
출처 데이터셋: uspto-grants-1998_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05824690

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