1-Benzylazepan-4-one hydrochloride → 1-benzyl-5-chloro-2,3,6,7-tetrahydro-1H-azepine-4-carbaldehyde hydrochloride

HRID 400114노트

반응식

HRID 400114 반응식
[ClH:1].[CH2:2]([N:9]1[CH2:15][CH2:14][CH2:13][C:12](=O)[CH2:11][CH2:10]1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.CN(C)[CH:19]=[O:20].P(Cl)(Cl)([Cl:24])=O>C(Cl)Cl>[ClH:24].[CH2:2]([N:9]1[CH2:15][CH2:14][C:13]([CH:19]=[O:20])=[C:12]([Cl:1])[CH2:11][CH2:10]1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

참가 물질

4

반응물 2

HCID 130720291-Benzylazepan-4-one hydrochlorideHCID 13765457DMF Phosphorus oxychloride

생성물 1

HCID 189435411-benzyl-5-chloro-2,3,6,7-tetrahydro-1H-azepine-4-carbaldehyde hydrochloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Prepared from 1-benzylhexahydro-4-azepinone hydrochloride by reaction with dimethylformamide/phosphorus oxychloride in methylene chloride at 20°-35° C.

출처 및 근거

ORD 기록
ord-ade65bfcd2d1453199638053f587eedf
출처 데이터셋
uspto-grants-1998_10
특허 번호
US05827849

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