Ether hydrochloride → 1-Benzyl-2-isopropyl-6-methoxy-1H-indole

HRID 40031노트

반응식

HRID 40031 반응식
[CH2:1]([N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([O:17][CH3:18])[CH:15]=2)[CH:10]=[C:9]1[C:19](O)([CH3:21])[CH3:20])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.CCOCC>CCOC(C)=O.CCO.[Pd]>[CH2:1]([N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([O:17][CH3:18])[CH:15]=2)[CH:10]=[C:9]1[CH:19]([CH3:21])[CH3:20])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

6

반응물 2

HCID 10953452Ether hydrochlorideHCID 597622752-(1-benzyl-6-methoxy-1H-indol-2-yl)propan-2-ol2회

생성물 1

HCID 597624051-Benzyl-2-isopropyl-6-methoxy-1H-indole

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 702Ethanol용매HCID 8857Ethyl Acetate용매

실험 절차

To a solution of 2-(1-benzyl-6-methoxy-1H-indol-2-yl)propan-2-ol (Compound 3, 1.05 g, 3.57 mmol) in EtOAc (35 ml) and EtOH (15 ml) was added 10% Pd—C (190 mg, 0.18 mmol) and HCl-Et2O (1.0 M, 1.25 ml, 1.25 mmol). The mixture was stirred under hydrogen gas (atmospheric pressure) for 1 h and was filtered. To the filtrate was added NaHCO3 (0.5 g) and H2O (0.5 ml), followed by Na2SO4 and MgSO4. This was then filtered and concentrated in vacuo to yield the crude title compound as a yellow solid.

후처리

  1. filtrationwas filtered
  2. additionTo the filtrate was added NaHCO3 (0.5 g) and H2O (0.5 ml)
  3. filtrationThis was then filtered
  4. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-8ecb303fb22d4ec4a259e5a2f652ee4c
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08524917B2

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