Cesium fluoride → 2-(4'-Chloro-4-ethyl-2'-methylbiphen-3-yl)-4,4-dimethyl-cyclohexane-1,3-dione

참여 물질

역할	이름	HCID	투입량
반응물	Cesium fluoride	HCID 25953	—
반응물	(4-Chloro-2-methylphenyl)boronic acid	HCID 5017600	—
반응물	2-(5-Bromo-2-ethylphenyl)-4,4-dimethylcyclohexane-1,3-dione	HCID 66870121	—
촉매	Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+)	HCID 178418228	—
용매	1,2-Dimethoxyethane	HCID 8071	—
생성물	2-(4'-Chloro-4-ethyl-2'-methylbiphen-3-yl)-4,4-dimethyl-cyclohexane-1,3-dione	HCID 123715133	—

반응 조건

온도	80 °C

반응 단계

A mixture of 2-(5-bromo-2-ethylphenyl)-4,4-dimethylcyclohexane-1,3-dione (0.194 g, 0.6 mmol), 2-methyl-4-chloro-phenylboronic acid (0.153 g, 0.9 mmol), [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (complex with dichloromethane 1:1) (80 mg, 0.098 mmol) and cesium fluoride (0.608 g, 4 mmol) are stirred together in 1,2-dimethoxyethane (4 ml) and the reaction mixture is heated at 80° C. overnight. The warm reaction mixture is filtered, washing the filter cake with 9:1 dichloromethane:methanol. The mixture is concentrated under reduced pressure and the residue is purified by column chromatography on silica gel to give 2-(4′-chloro-4-ethyl-2′-methylbiphen-3-yl)-4,4-dimethyl-cyclohexane-1,3-dione.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08741806B2
출처 데이터셋	uspto-grants-2014_06
ORD ID	ord-2b6c5141eef649918800f0a6fff9105f
출처 메모	uspto-grants-2014_06