Triethylammonium hydroxide → HCID 86686051, 화합물

HRID 400453노트

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HRID 400453 반응식
[OH-].C([NH+](CC)CC)C.[C:9]([NH:12][CH:13]1[C:17](=[O:18])[CH2:16][N:15]([C:19]([O:21][CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)=[O:20])[CH2:14]1)(=O)[CH3:10]>C1COCC1>[CH2:22]([O:21][C:19]([N:15]1[CH2:16][C:17]2[O:18][C:9]([CH3:10])=[N:12][C:13]=2[CH2:14]1)=[O:20])[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1

참가 물질

4

반응물 2

HCID 21903323Triethylammonium hydroxideHCID 86686050Benzyl 3-acetamido-4-oxopyrrolidine-1-carboxylate

생성물 1

HCID 86686051HCID 86686051, 화합물수율 31.9%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

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온도
65 °C

실험 절차

8.5 g methoxycarbonylsulfamoyl)triethylammoniumhydroxid was added to 4.7 g benzyl 3-acetamido-4-oxopyrrolidine-1-carboxylate in 180 mL THF. The reaction was stirred 1 h at 65° C. and evaporated. The residue was purified on silica gel (hexane/ethyl acetate:1/1) to give 1.4 g of the desired product.

후처리

  1. customevaporated
  2. customThe residue was purified on silica gel (hexane/ethyl acetate:1/1)

출처 및 근거

ORD 기록
ord-560ac167e85d483599e1a10467826ce3
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08741892B2

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