Hydrazine → 3,5-bis(4-fluorophenyl)-1H-pyrazole

HRID 400484

반응식

HRID 400484 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=O)[CH2:9][C:10]([C:12]2[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=2)=O)=[CH:4][CH:3]=1.[NH2:20][NH2:21]>C1COCC1>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=3)[NH:21][N:20]=2)=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 9321HydrazineHCID 738961,3-Propanedione, 1,3-bis(4-fluorophenyl)-

생성물 1

HCID 161054793,5-bis(4-fluorophenyl)-1H-pyrazole

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
75 °C

실험 절차

3.9 g 1,3-Bis-(4-fluoro-phenyl)-1,3-propandione was dissolved in 45 mL of a solution of 1 N hydrazine in THF and stirred for 2 h at 75° C. The solvent was removed to give 3.6 g of the desired compound. Rt: 1.03 min (method D), (M+H)+: 257

후처리

  1. customThe solvent was removed

출처 및 근거

ORD 기록
ord-a728c573b75d463ea14b56975bd2d7d7
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08741892B2

연결된 노트

불러오는 중…