Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ammonia → HCID 71586646, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ammonia | HCID 222 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | (3,5-Diphenyl-pyrazol-1-yl)-acetic acid | HCID 824607 | — |
| 반응물 | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| 반응물 | 5-Chloro-2-(4-piperidinyl)pyrimidine | HCID 55262357 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 용매 | Methanol--water (1/1) | HCID 22242641 | — |
| 생성물 | HCID 71586646 | HCID 71586646 | 23.9% |
반응 단계
28 mg (3,5-diphenyl-pyrazol-1-yl)-acetic acid was dissolved in 2 mL DMF and 26 mg DIPEA and 32 mg TBTU were added to this solution and the reaction was stirred for 5 minutes at RT. The mixture was added to 20 mg 5-chloro-2-piperidin-4-ylpyrimidine and stirred for 2 h. The reaction was cleaned by RP-chromatographie (methanol/water, 0.1% NH3) to yield 11 mg of the desired compound. Rt: 2.38 (method A), (M+H)+: 458
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08741892B2 |
| 출처 데이터셋 | uspto-grants-2014_06 |
| ORD ID | ord-49ba1563701549929f09c701a9524617 |
| 출처 메모 | uspto-grants-2014_06 |