4-Hydroxy-3-methylbenzonitrile → HCID 67141374, 화합물

HRID 400593노트

반응식

HRID 400593 반응식
[OH:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][C:3]=1[CH3:10].F[B-](F)(F)F.[O:16]=[N+:17]=[O:18]>C(#N)C.O>[OH:1][C:2]1[C:9]([N+:17]([O-:18])=[O:16])=[CH:8][C:5]([C:6]#[N:7])=[CH:4][C:3]=1[CH3:10]

참가 물질

5

반응물 2

HCID 109645604-Hydroxy-3-methylbenzonitrileHCID 11073463Nitronium tetrafluoroborate

생성물 1

HCID 67141374HCID 67141374, 화합물수율 94%

시약·촉매·용매 2

HCID 962Water용매HCID 6342Acetonitrile용매

실험 절차

A stirred solution of 4-hydroxy-3-methylbenzonitrile (3.1 g, 23.3 mmol) in 60 mL of anhydrous acetonitrile was cooled to −30° C. and treated with nitronium tetrafluoroborate (3.4 g, 25.6 mmol) in portions. After 60 minutes, the reaction mixture was diluted with 100 mL of water. The resulting light yellow precipitate was filtered, washed with water, and dried to give 3.9 g of 4-hydroxy-3-methyl-5-nitrobenzonitrile (94% yield).

후처리

  1. filtrationThe resulting light yellow precipitate was filtered
  2. washwashed with water
  3. customdried

출처 및 근거

ORD 기록
ord-9bd1239af7614a7b8aafa67a12e09874
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08741897B2

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