Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 40062생성일: 2026년 10월 25일
Potassium Carbonate → Ethyl3-Formyl-2-isopropyl-1-(pyridin-2-ylmethyl)-1H-indole-6-carboxylate
https://huagongshe.com/reaction/40062
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 2-(Bromomethyl)pyridine | HCID 564209 | — |
| 반응물 | Ethyl3-Formyl-2-isopropyl-1H-indole-6-carboxylate | HCID 59762423 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | Ethyl3-Formyl-2-isopropyl-1-(pyridin-2-ylmethyl)-1H-indole-6-carboxylate | HCID 86621603 | — |
반응 단계
Following General Procedure C, ethyl3-formyl-2-isopropyl-1H-indole-6-carboxylate (Compound 34, 278 mg, 1.07 mmol) in DMF (15 ml) was added K2CO3 (590 mg, 4.28 mmol) and 2-(bromomethyl)pyridine (914 mg, 5.35 mmol). The reaction was stirred at 60° C. for 5 h, diluted with EtOAc, washed with H2O, brine, dried over Na2SO4 and concentrated in vacuo. The residue was purified by chromatography on silica gel (0→35% EtOAc-hexanes) to yield the title compound as a yellow oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08524917B2 |
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| 출처 데이터셋 | uspto-grants-2013_09 |
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| ORD ID | ord-5bfec063a8974500a36e692c56931387 |
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| 출처 메모 | uspto-grants-2013_09 |
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